Detalhe da pesquisa
1.
A Small Molecule Targeting Mutagenic Translesion Synthesis Improves Chemotherapy.
Cell
; 178(1): 152-159.e11, 2019 06 27.
Artigo
Inglês
| MEDLINE | ID: mdl-31178121
2.
Methotrexate recognition by the human reduced folate carrier SLC19A1.
Nature
; 609(7929): 1056-1062, 2022 09.
Artigo
Inglês
| MEDLINE | ID: mdl-36071163
3.
Manassantin A inhibits tumour growth under hypoxia through the activation of chaperone-mediated autophagy by modulating Hsp90 activity.
Br J Cancer
; 128(8): 1491-1502, 2023 04.
Artigo
Inglês
| MEDLINE | ID: mdl-36759727
4.
Structural basis of the UDP-diacylglucosamine pyrophosphohydrolase LpxH inhibition by sulfonyl piperazine antibiotics.
Proc Natl Acad Sci U S A
; 117(8): 4109-4116, 2020 02 25.
Artigo
Inglês
| MEDLINE | ID: mdl-32041866
5.
REV1 inhibitor JH-RE-06 enhances tumor cell response to chemotherapy by triggering senescence hallmarks.
Proc Natl Acad Sci U S A
; 117(46): 28918-28921, 2020 11 17.
Artigo
Inglês
| MEDLINE | ID: mdl-33168727
6.
Structure- and Ligand-Dynamics-Based Design of Novel Antibiotics Targeting Lipid A Enzymes LpxC and LpxH in Gram-Negative Bacteria.
Acc Chem Res
; 54(7): 1623-1634, 2021 04 06.
Artigo
Inglês
| MEDLINE | ID: mdl-33720682
7.
Structural insights into inhibition of lipid I production in bacterial cell wall synthesis.
Nature
; 533(7604): 557-560, 2016 05 26.
Artigo
Inglês
| MEDLINE | ID: mdl-27088606
8.
Synthetic efforts toward the bicyclo[3.2.1]octane fragment of rhodojaponin III.
Tetrahedron Lett
; 712021 May 11.
Artigo
Inglês
| MEDLINE | ID: mdl-34054153
9.
Length Specificity and Polymerization Mechanism of (1,3)-ß-d-Glucan Synthase in Fungal Cell Wall Biosynthesis.
Biochemistry
; 59(5): 682-693, 2020 02 11.
Artigo
Inglês
| MEDLINE | ID: mdl-31899625
10.
Synthesis and evaluation of sulfonyl piperazine LpxH inhibitors.
Bioorg Chem
; 102: 104055, 2020 09.
Artigo
Inglês
| MEDLINE | ID: mdl-32663666
11.
Synthesis and Analysis of Natural-Product-Like Macrocycles by Tandem Oxidation/Oxa-Conjugate Addition Reactions.
Chemistry
; 25(26): 6500-6504, 2019 May 07.
Artigo
Inglês
| MEDLINE | ID: mdl-30912197
12.
Synthetic efforts towards the stereoselective synthesis of NF00659B1.
Bioorg Med Chem Lett
; 28(16): 2746-2750, 2018 09 01.
Artigo
Inglês
| MEDLINE | ID: mdl-29503022
13.
Formal Synthesis of (+)-Laurencin by Gold(I)-Catalyzed Intramolecular Dehydrative Alkoxylation.
Chemistry
; 23(30): 7180-7184, 2017 May 29.
Artigo
Inglês
| MEDLINE | ID: mdl-28393406
14.
Synthesis and biological evaluation of largazole zinc-binding group analogs.
Bioorg Med Chem
; 25(12): 3077-3086, 2017 06 15.
Artigo
Inglês
| MEDLINE | ID: mdl-28416100
15.
Discovery of Manassantin A Protein Targets Using Large-Scale Protein Folding and Stability Measurements.
J Proteome Res
; 15(8): 2688-96, 2016 08 05.
Artigo
Inglês
| MEDLINE | ID: mdl-27322910
16.
Advances in the synthesis of glycosidic macrolides: clavosolides A-D and cyanolide A.
Nat Prod Rep
; 33(12): 1393-1424, 2016 Nov 23.
Artigo
Inglês
| MEDLINE | ID: mdl-27714078
17.
Subglutinol A, an immunosuppressive α-pyrone diterpenoid from Fusarium subglutinans, acts as an estrogen receptor antagonist.
Biochem Biophys Res Commun
; 461(3): 507-12, 2015 Jun 05.
Artigo
Inglês
| MEDLINE | ID: mdl-25896764
18.
Total Synthesis of Clavosolide A via Tandem Allylic Oxidation/Oxa-Conjugate Addition Reaction.
Tetrahedron Lett
; 56(23): 3120-3122, 2015 Jun 03.
Artigo
Inglês
| MEDLINE | ID: mdl-26236051
19.
Natural product synthesis at the interface of chemistry and biology.
Chemistry
; 20(33): 10204-12, 2014 Aug 11.
Artigo
Inglês
| MEDLINE | ID: mdl-25043880
20.
Evaluation of class I HDAC isoform selectivity of largazole analogues.
Bioorg Med Chem Lett
; 24(16): 3728-31, 2014 Aug 15.
Artigo
Inglês
| MEDLINE | ID: mdl-25070421